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Assessments In order to measure pharmacokinetic parameters, 6 mL of blood was collected from a vein in the forearm using an indwelling catheter with a switch valve

Additional information The authors would like to dedicate this article to Dr Fabrice Morel who passed away during the preparation of the manuscript

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ACTIVE ZONE A portion of the presynaptic membrane that faces the postsynaptic density across the synaptic cleft